Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer. Both are the focus of an intensive effort in the department of nutritional sciences at The University of Arizona to find natural, biologically active compounds that will sensitize the cancerous tumors to therapy without damaging normal tissue. By using the compounds in conjunction with conventional treatment, the researchers hope patient survival rates will ultimately increase.
The incidence of melanoma, an aggressive and often fatal form of skin cancer, is increasing at the rate of 3 percent annually, according to the American Cancer Society. Dacarbazine, the standard chemotherapeutic drug for melanoma for decades, has been ineffective when used alone. To improve its performance, Randy Burd, assistant professor of nutritional sciences and member of the UA's BIO5 Institute, has been testing the drug and its new analog Temozolomide in combination with various bioactive compounds to gain greater response rates on melanoma tumors in cell cultures.