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Study of the genetics of small molecule natural product (antibiotics and other bioactive compounds) biosynthesis in microbes (bacteria and fungi). Engineering of natural product biosynthesis to achieve production of altered molecules and improved yields.
Xu Y, Orozco R, Kithsiri Wijeratne EM, Espinosa-Artiles P, Leslie Gunatilaka AA, Patricia Stock S, Molnár I. May 2009. Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana. Fungal Genet Biol, 46:353-64
Xu Y, Wijeratne EM, Espinosa-Artiles P, Gunatilaka AA, Molnár I. Jan 2009. Combinatorial mutasynthesis of scrambled beauvericins, cyclooligomer depsipeptide cell migration inhibitors from Beauveria bassiana. Chembiochem, 10:345-54
Coleman JJ, Rounsley SD, Rodriguez-Carres M, Kuo A, Wasmann CC, Grimwood J, et al.. Aug 2009. The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion. PLoS Genet., 5:e1000618
Xu Y, Orozco R, Wijeratne EM, Gunatilaka AA, Stock SP, Molnár I. Sep 2008. Biosynthesis of the cyclooligomer depsipeptide beauvericin, a virulence factor of the entomopathogenic fungus Beauveria bassiana. Chem Biol, 15:898-907